Sulforaphane is found in broccoli sprouts. It is highly bioavailable with extremely low toxicity. There are many in vitro and in vivo animal studies as well as many human studies showing its clinical efficacy in cancer.
It possesses anti-angiogenesis activity and anti-metastasis activity. It also inhibits many metabolic pathways including the inhibition of hypoxia inducible factor, nuclear factor kappa beta and down regulation of vascular growth factor as well as MMP 9. It has many cancer killing effects.
In 2010 and 2013 Dr. Zhang studied sulforaphane in a breast cancer model. He found it “highly potent” for elimination of breast circulating cancer stem cells. Cyclin D1 levels were decreased by 80-85%.
Sulforaphane does reach therapeutic blood levels in approximately 1 hour. In 2007 a pilot study was done on 8 healthy women undergoing reduction mammoplasty. They were given a single dose of broccoli sprouts one hour before surgery. When the breast tissue in the removed surgical specimen was examined, metabolites were measured and were effective against breast cancer circulating cells.
It also targets pancreatic tumor initiating cells by NF kappa B induced anti- apoptotic signaling.
There has been in vitro and in vivo studies with pancreatic cancer stem cells, triple negative breast cancer stem cells, lung cancer stem cells, gastric cancer stem cells, oral squamous cancer stem cells and chronic leukemia stem cells.
In 2008, Dr. Clark found that sulforaphane depleted glutathione by 90% in cancer cells which helped to kill the cancer. It has been shown to inhibit prostate cancer cells by down regulating intracellular glutathione and increasing reactive oxygen species causing cancer mitochondrial apoptosis (cancer cell death).
In 2015 Dr. Cipolla did a double blinded, randomized, placebo-controlled trial. The study had 78 males with a rising PSA levels after radical prostatectomy for prostate cancer. It slowed the PSA doubling time from 15.5 months down to 28.9 months. It prolonged PSA doubling time thereby delaying “biochemical recurrence”.
Since it also induced protective autophagy, the author suggested that the activity may be enhanced by simultaneous treatment with an inhibitor of autophagy. These might include propranolol, doxycycline, and other repurposed cancer drugs.
If you would like more information about sulforaphane, re-purposed cancer drugs, evaluation of your circulating cancer stem cells, chemosensitivity testing, natural testing, low dose metronomic targeted genomic chemotherapy and cancer vaccines we can help.
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