The clues of neuronal death in Parkinson’s disease are still unknown, but a new study purposes that that neurons may be mistaken for foreign invaders and kill by the patients own immune system, similar to the way autoimmune diseases like type I diabetes, celiac disease, multiple sclerosis, and Crohn’s disease does. This was published in April 16, 2014, in Nature Communications.
Autoimmune disease is one of alerted TH1, TH2, balances resulting in the body attacking itself. When the immune system recognizes the body is nonself.
Along with the autoimmune causes there is also an increased mitochondrial dysfunction with increased reactive options in species and altered glutamatergic neurotransmission resulting in neuronal metabolic dysfunction. This appears to be central to the pathophysiology of Parkinson’s disease.
The substantia nigra pars, the area where the primary pathological lesion is located is particularly exposed to oxidative stress (free radicals) and toxic and metabolic insults.
A reduced capacity to cope with metabolic demands related to impaired mitochondrial function, makes the nigral highly vulnerable to glutamate, this glutamate acts as a neurotoxin in the presence of impaired cellular mitochondrial energy. In this way, glutamate may participate in the pathogenesis. There is evidence of dopamine depletion and increased glutamatergic activity.
WHAT CAUSES THE INITIAL INSULT?
If patients have evidence of increased glutamate resulting in neuronal cell death and mitochondrial dysfunction with increased free radicals, the question is what is the initiating cause? What causes an organism response?
Multiple theories have been proposed and these include infections such as lyme, ehrlichia, Babesia, Bartonella, chlamydia, and mycoplasma.
In addition multiple viruses have been implicated, as well as parasites and protomyxzoa( FL 1953 ) These organisms form a biofilm which results in subsequent chronic cerebrospinal vascular insufficiency and stenosis of the cerebral veins resulting in increased irritable blood flow.
Subsequent to this there are increased inflammation, increased TNF alpha, increased free radical damage, increased mitochondrial dysfunction, and glutamate toxicity resulting in neuronal cell death.
In addition to infection, we need to also look at heavy metals, especially mercury which can directly affect neuronal survival time, as well resulting in glutathione depletion. Glutathione is needed by the nerve cell. In addition to the above electromagnet fields might also be implicated.
Recent research has shown that gluten and related foods that cross react with gluten can cross the blood brain barrier and initiate neuronal death.
In traumatic brain injury there is loss of dopaminergic neurons and disruption of the blood brain barrier. This leads to chronic inflammation and activation of glial cells, with activation of specific inflammatory pathways associated with blood brain barrier dysfunction and neuronal death. TGFB 1 and other inflammatory cytokines have been implicated in the progression of the disease.
INTEGRATIVE TREATMENT OF PARKINSON’S
My approach to Parkinson’s is multifaceted.
Obviously, there is mitochondrial dysfunction with increased free radical damage and neuronal death. This is measured in my patients. There are usually abnormalities and Krebs cycle intermediates which are also measured.
In additional the is increased inflammation and a underlying autoimmune pathology
Infections such as lyme, ehrlichia, Babesia, Bartonella, virus, parasite, and protomyxzoa, especially FL1953 might also be implicated. There are known to cause chronic biofilm, which may on occasion result in chronic cerebrospinal venous insufficiency and stenosis. This would result in decreased cerebral blood flow with hypoxia and result in decreased oxygen utilization. This would aggravate the free radicals as well as the inflammatory cascade.
My approach is to look for underlying infections, as well as heavy metals and biofilm.
Evaluation of chronic cerebrospinal venous insufficiency is also undertaken with Trans Doppler studies. If this is positive, then other appropriate dilation therapies might be entertained.
Autoimmune imbalances with a complex cytokine evaluation is undertaken. This evaluates TH1, TH2, T REG, and T17 cytokines.
A complete autoantibody assessment to all brain tissue including the blood brain barrier, and brain neurotransmitters is evaluated.
In addition all possible inducers is studied, including chemicals, food, and heavy metals. A battery of many gluten antibody tests are preformed, as well as foods that cross react with gluten are evaluated.
Mitochondrial dysfunction is evaluated, as well as hormones and other toxins implicated. These include pesticides and other environmental toxins. All causes of reversible autoimmunity are investigated.
Spect brain scans are also ordered to quantitate the amount of dopamine receptors in the brain.
THE AIM OF THE TREATMENT IS TO IMPROVE DOPAMINERGIC TRANSMISSION
After autoantibody assessment, cytokine evaluation, mitochondrial evaluation, neurotransmitter evaluation evaluation of heavy metals, infections, toxins, gastro intestinal, gluten and cross reactions and gene testing a personalized program is instituted.
IV nutritionals with glutathione, Plaquex, myers cocktail, ozone and others along with hyperbaric oxygen treatments (HBO) , pulsed electromagnetic field therapy ( PEMF) with a 19,000 gauss strength, far infrared sauna, lymphatic detoxification, especially around the cerebral area, as photon therapy ( LIGHT BEAM GENERATOR WITH OZONE) and microcurrent is used.
To address lowering glutamate oxaloacetate is used in addition to other natural substances. If there is evidence of increased inflammation then this is treated appropriately. Offending foods are removed.
Precursors using natural dopamine agonist are also added to balance the neurotransmitters. Urinary levels are evaluated and optimized.
The patient is counseled on why food choices to lower glutamate in addition to other supplements which strengthen neuronal integrity.
In addition to this, intravenous OZONE is used under an investigational research board study to improve oxygen to the brain, modulate autoantibodies, lower inflammation and lower free radicals.
There is also a new spect brain scan to see how much dopamine your brain has.
ASK DR. SILVER IF YOU ARE A CANDIDATE FOR STEM CELLS.
If you suffer from Parkinson’s disease and wish to be evaluated in an integrative approach, please call my office for an appointment. I also use standard medications in my treatments, but I feel that a integrative approach is best.
Best in health,
Dean R. Silver, M.D.