Immunotherapy Therapy and Integrative Cancer Care
Immunotherapy with dendritic cell vaccines, checkpoint inhibitors and supportive Oligonucleotides (SOT) are now available now. Too many people are being denied this form of treatment. I feel combination therapy with all three is the best because they all help you to kill your cancer. We use this with low-dose targeted chemo therapy and natural substances for the best possible outcomes. This is the future of an integrative cancer treatment.
I am a cancer survivor for 20 years. At the Silver cancer institute in Scottsdale Arizona who specializes in integrative oncology. I am a member of the Society for Immunotherapy of Cancer. If you have been told by your doctor that immunotherapy will not work, or you are not a candidate for immunotherapy please read this in great detail. I believe that many more people should be offered immunotherapy, but at the present time are not receiving it.
Immunotherapy has revolutionized the way I treat cancer in Scottsdale Arizona at the Silver Cancer Institute. Immunotherapy helps your body’s own immune system to fight your cancer. Training our immune system to respond to cancer has the potential for a longer response that can extend beyond the end of treatment. This makes it a very different form from the other types of cancer treatments. Over the last several years the indications for using immunotherapy and checkpoint inhibitors are rapidly expanding to include many more forms of cancer.
YOU MUST HAVE THESE TESTS
By measuring tumor mutational burden, microsatellite instability, and PD-L1 we can determine the cancer’s response or susceptibility to the checkpoint inhibitors. This test, by using genomic bio-markers, will expand the candidates for whom immunotherapy with checkpoint inhibitors will work. This test will allow millions of more cancer patients to receive immunotherapy. What this means is that when the mutation rate is high or there was instability the tumor is hot and will respond to these treatments.
Tumors that are defective in DNA mismatch repair genes have higher levels of microsatellite instability and therefore carry a higher mutational burden. Clinical data from these markers has made this the first FDA approval of cancer therapy based on biomarkers regardless of the cancer type. In my opinion, every patient should have this test to determine accurate and effective immunotherapy. This will make immunotherapy with checkpoint inhibitors available for millions of more people. At this office I use a combination approach with the use of Dendritic cell vaccines, checkpoint inhibitors and supportive oligo-nucleotides.
Cancer immunotherapy helps regulate the immune system to control cancer. The therapy enhances the ability of our immune cells to first recognize then destroy cancer cells. One of the immunotherapies used is called check point inhibitors. These turn on the switch and allow our own T-cells to destroy cancer.
Check point inhibitors work best when the tumor has many mutations and is considered a “hot” tumor. In tumors that are considered “cold”, immunothera-py has not been shown to be effective. Other forms of immunotherapy include oncolytic virus therapy, dendritic cell vaccines, interleukin-2, and interferon. We have developed protocols to help turn cold tumors into hot tumors for more effective response to the immunotherapy.
Dendritic Cell Vaccines
I also use dendritic cell vaccines in my cancer protocols. The cells must be isolated from a patient and cultured in vitro during which time they are loaded and posted with specific antigens. They are then re-introduced into the patient to help process and deliver the cancer cell to our immune fighting cells to fight your cancer. There are preliminary immunity testing which needs to be optimized prior to their administration. Several doses may be necessary. This will also help the checkpoint inhibitors to kill your cancer more efficiently because the tumor is now hot and active susceptible to checkpoint inhibitors.
Supportive Oligonucleotide Technique (SOT)
A similar technique called antisense has been known to have been used for at least 15 years; however, there are major differences between antisense as traditionally used and SOT has the ability to induce apoptosis (cell death) in the circulating cancer stem cells and circulating cancer tumor cells, and all primary and metastatic tumors. This is regardless of the size and most notably it is able to cross the blood brain barrier with ease. The SOT will remain active in the blood stream for approximately 14-16 weeks but may be longer per dose. Be-cause, the messenger RNA actually features a stealth like ability that keeps the body from recognizing and destroying it, only 3 SOT doses are allowed in any 12-month period. Also, we can use SOT therapy for any type of infection including Lyme, mold, and HIV, etc.
Immunotherapy therapy, also called biologic therapy, is a type of cancer treatment designed to boost the body's natural defenses to fight the cancer. It uses materials either made by the body or in a laboratory to improve, target, or restore immune function. It works in the following ways:
- Stopping or slowing the growth of cancer cells.
- Stopping cancer from spreading to other parts of the body.
- Helping the immune system work better at destroying cancer cells.
I believe that testing for specific chemotherapy drugs, natural substances, and immunotherapy is important. This testing allows us to formulate a personalized genomic based protocol for treatment. By targeting different genetic abnormalities, we can offer you truly personalized therapy for the best possible outcome. We feel that the indications for immunotherapy will be expanding in the future. Right now, there are only a few FDA approved therapies for certain cancers. We believe that immunotherapy should be used in anyone that it may be beneficial for. If you were told you were not a candidate for immunotherapy, please consider calling me.
Immunotherapy with checkpoint inhibitors, dendritic cells vaccines, cytokines therapy, and supportive oligonucleotides are available now in this office. They should be used in combination with low-dose chemo therapy and natural sub-stances