The predominant metabolic process in cancer cells is called aerobic glycolysis. To block this would help with certain cancers. As oxygen levels drop there is the production of lactic acid. In response to the hypoxia or low oxygen the tumor cells produce new oncogenes and modify their pathways to survive and grow. 2 deoxyglucose is a synthetic glucose analog in which the 2-hydroxyl group if he placed by hydrogen. There is subsequent inhibition of glucose metabolism blocking tumor growth.
2 deoxy glucose has been shown to inhibit Hexokinase II, which catalyzes the initial metabolic step in the conversion of glucose to energy. This can then be used as an anticancer therapy. The good news is that 2 deoxy glucose can cross the blood-brain barrier and is quickly taken up by cancer cells not only in the brain but all over the body.
Prolonged autophagy and extensive self-degradation lead to cancer cell death. 2 deoxy glucose is a potent inducer of apoptosis. It also generates extensive free radicals to help impede tumor growth.
It can also inhibit ATP synthesis as well as disrupt metabolism of proteins and lower NAD and glutathione levels. It also appears to be an effective cytotoxic agent. Moreover, it has a unique ability to affect cancer cells under low oxygen conditions, which often limits traditional chemotherapy. It is a promising candidate for not only monotherapy but also in combination with low dose chemotherapy natural substances cancer vaccines and radiotherapy.
It has been shown to sensitize cancer cells to cytotoxic drugs to which they are resistant when used alone this includes doxorubicin, cisplatin, and gemcitabine. It also sensitize cells with radiotherapy
It has been studied in head and neck cancers, bladder cancer, glioblastoma, breast cancer, ovarian cancer, small lung carcinomas, thyroid carcinoma, colon cancer, thyroid cancer, non-small cell lung cancer, leukemia, pancreatic cancer, osteosarcoma, and others.
2 deoxy glucose should always be used in combination therapy. We also evaluate circulating cancer stem cells, chemosensitivity testing for low-dose genomic chemotherapy, natural substances, vaccine therapy and re-purposed cancer drugs.
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